STARD3: A Prospective Target for Cancer Therapy

Cancer is one of the major causes death in developed countries and current therapies are based on surgery, chemotherapeutic agents, radiation. To overcome side effects induced by chemo- radiotherapy, recent decades, targeted have been proposed second even first lines. Targeted drugs act essential pathways involved tumor induction, progression, metastasis, basically all hallmark cancers. Among emerging pathways, cholesterol metabolic pathway a strong candidate for this purpose. cells an accelerated rate require continuous supply cell division membrane renewal. Steroidogenic acute regulatory related lipid transfer (START) proteins family lipids some them important non-vesicular transportation within cell. The alteration their expression levels implicated several diseases, including In review, we report latest discoveries StAR-related protein domain 3 (STARD3), member START family, which has potential role cancer, focusing structural biochemical characteristics mechanisms that regulate its activity. STARD3 as molecular target development cancer also discussed. As key movement cells, it interest to identify inhibitors able block